Combination Treatment of Murine Tumors by Adenovirus-Mediated Local B7/IL12 Immunotherapy and Radiotherapy

Combination of Immunotherapy & Radiotherapy for the Treatment of Prostate Cancer

etiology, significance, diagnosis and treatment of bruxiam

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Enhanced cures of spontaneous murine mammary tumors with surgery, combination chemotherapy, and immunotherapy.

Significant numbers of cures of spontaneous mammary adenocarcinoma in CD8F, 9 (BALB/c 9 X DBA/8 Õ) mice have been effected by concomitant administration of three therapeutic modalities: surgery (enucleation) + combination chemotherapy + immunotherapy (nonspe cific immunological adjuvant). The results were obtained following lifetime observation of the animals. Immunotherapy consisted of zymosa...

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

While immunotherapy employing chimeric antigen receptor (CAR) T cells can be effective against a variety of tumor types, little is known about what happens within the tumor at an ultrastructural level during tumor regression. Here, we used transmission electron microscopy to investigate morphologic and cellular features of tumors responding to immunotherapy composed of adoptive transfer of dual...

Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy.

The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide. This allows treatment of thyroid cancers with 131I. We propose to enlarge this therapeutic strategy to nonthyroid tumors by using an adenoviral vector to deliver the NIS gene into the tumor cells. We constructed a recombinant adenovirus encoding the rat NIS ...